Jan 18, 2017 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to presents its January meeting at, PRINCETON, Wednesday, January 18, 2017. [ register ]

Featured Presentation

Dr. Purnima Khandelwal

Bristol-Myers Squibb

“Polyethylene Glycol (PEG) Quantitation in Biofluids supporting Drug Discovery”

Abstract:

Conjugation of macromolecular drugs to polyethylene glycol (PEG) improves their therapeutic potential by enhancing the half-life. As a substantial component of the drug, it is necessary to measure the pharmacokinetic (PK) characteristics of PEG in vivo. A quantitative NMR-based method was developed and applied to measuring 40 kDa PEG in serum, enabling determination of PK parameters in preclinical species. Observed half-life was found to be consistent with 125Iodine-labeled PEG methods. Moreover, urinary quantitation of 20kDa PEG  was used to investigate side effects of a pegylated biologic. NMR spectroscopy was shown to be a convenient and reliable alternative to follow pharmacokinetics of PEG in various biofluids.

Program

6:00 pm   Dinner
7:00 pm  Seminar

Meeting Venue

Frick Chemistry Atrium (dinner), Frick Chemistry room A81 (seminar), Princeton University, Princeton NJ 08540  [ directions ]

Dinner Cost:

$15 employed.
$5 for students postdoc, retired, unemployed
No charge for seminar only

Questions:

Anuji.Abraham@bms.com or Mary.Harner@bms.com

Register:

Please register online here or via e-mail to Anuji Abraham  Anuji.Abraham@bms.com or Mary Harner Mary.Harner@bms.com