Jun 28, 2017 – MSDG Meeting

A different approach to electrospray LC/MS using flow-based ion transport in to the mass spectrometer better resists changes in performance due to contamination.  Using the flow of the nebulizing gas to entrain ions in to the system eliminates the need for a high voltage ion funnel or charged capillary and eliminates a number of parameters such as desolvation potential.  The result is better long term stability, sensitivity, fewer variables and much lower maintenance.  This is especially evident with more challenging sample matrices.  The talk includes relevant application examples that demonstrate this principle and other benefits of the design.
Bio:
Mark Greenbaum has been associated with analytical chemistry and the analytical instruments industry for over 30 years.  He has been involved in LC/MS, liquid chromatography, atomic force microscopy, scientific software and others.  He worked with the inventors of the QSight LC triple quad and came to PerkinElmer with the acquisition of the technology.   His most recent work representing QSight makes him uniquely qualified to speak about the system, its use and LC-MS/MS.  Mark received his degree from the University of Maryland.

Jon Sims is a career chemist and recognized expert in trace metals analysis.  Jon’s ability as a Technical Advisor will enhance and support comprehensive solutions for the new USP (U.S. Pharmacopeia) <232><233><2232> regulations.  Jon is a recently retired analytical manager from pharmaceutical giant GlaxoSmithKline, where he helped develop and implement strategies for ICH (International Conference on Harmonization) Q3D, USP <232>.  He holds a BSc (Honors)in Chemistry from Loughborough University.  He is also a member of the Royal Society of Chemistry, Association for Laboratory Automation, and acts as a referee for the Journal of Pharmaceutical Sciences.